HOW TO RECOGNIZE AN ADVERSE DRUG REACTION – ANTIBIOTICS

Regularly, drug-induced reaction are often recognized by clinician and from the other perspective, the relationship between antimicrobial activity & development of an undesirable drug initiation can be very cunning and elude the most astute practitioner irrespective of these facts, the following step are helpful to establish the role of an antimicrobial drug in an adverse events;

Confirm that the medication ordered/dosage was administered to the later.
Verify that the onset of the adverse event was after the medication was given.
Record the adequate response to discontinuation of the particular drug.
Consult the scientific literature, sub-specialists and the drug manufacturer.
Unusual and life – threatening reactions should be reported to the food & drug administration spontaneous reporting system, as this observation can provide previously unsuspected, invaluable information.

If a compound is uniquely advantageous to a patient, a carefully controlled recalling can be considered to more precisely identify a cause-and-effect relationship. Measurement of serum drug concentrations helps confirm antibiotic induced toxicity especially when drug interactions are involved.