Abstract
Klebsiella pneumoniae, Streptococcus pyogenes, Candida albicans, Candida tropicalis, Candida krusei and Proteus mirabilis. The result indicated that the extracts inhibited the growth of one or more test .
The ethyl acetate extract showed a broad spectrum of antimicrobial activity.4-(4-Chlorophenyl)-3-cyclohexyl-1-methyl-6-(2- naphthoyl)-1,2,3,4-tetrahydro-1,2,4,5-Tetrazine was isolated from the ethyl acetate extract of the plant leaves by means of Vacuum liquid chromatography (VLC),
Thin layer chromatography (TLC) and Preparative thin layer chromatography (PTLC) using a solvent mixture of 1:1 v/v petroleum-ether and ethyl acetate.
The stucture was established mainly by MS, IR, 1H and 13C NMR including DEPT spectroscopy. Also the isolated compound was able to inhibit the growths of some of the microorganisms used for the studies.
The result of the study justified the use of the plant against several infectious diseases.
Introduction
1.1 Background of Study
Medicinal plants have always been associated with cultural behaviours and traditional knowledge. The renaissance of interest in plant products has been stimulated by the use of plant extracts in chronic conditions for which conventional drugs is perceived to offer very little specificity in its target (Rhiouani et al., 1999).
This has resulted in the use of large number of medicinal plants with curative properties to treat various diseases (Verpoorte, 1998).
Nearly 80% of the world‘s population relies on traditional medicines for primary health care, most of which involve the use of plant extracts (Akindele and Adeyemi, 2007).
The blind dependence on synthetics is over and people are returning to the naturals with hope of safety and security.
Also, the development of adverse effects and high microbial resistance to the chemically synthesized drugs, has forced men into ethnopharmacognosy.
More so, in our local situation, degree of ignorance and illiteracy had forced many to abandon or neglect pharmaceutically formulated drugs in favour of locally prepared herbal remedies coupled with the fact that pharmaceutical products are increasingly being faked.
Thus, the herbal products today symbolise safety in contrast to the synthetics that are regarded as unsafe to human and environment (Joy et al., 2001).
References
Adelani, P.O. (2007). Synthetic Pathway of 8 – Hydroxyl – 9, 10 – Dimethoxyanthracene –-Aldehyde (Oruwalol). European Journal of Scientific Research, 16(1): 44 – 54.
Adotey, J.P.K., Adukpo, G.E., Boahen, Y.O. and Armah, F.A. (2012). A Review of the Ethnobotany and Pharmacological Importance of Alstonia boonei De Wild (Apocynaceae). ISRN Phamacology Volume 2012, Article ID 587160, 9 pages Alkaloid – Wikipedia, the free encyclopedia
Akindele, A.J. and Adeyemi, O.O. (2007). Anti-inflammatory activity of the aqueous leaf extract of Byrsocarpus coccineus. Fitoterapia, 78: 25 – 28.
Alavi, S.H.R., Yassa, N., Hajiaghaee, R., Matin Yekta, M., Rezaei Ashtiani, N., Ajani, Y. and Hadjiakhondi, A. (2009). Phenolic compounds from Peucedanum ruthenicumBieb. Iranian Journal of Pharmaceutical Research, 8 (1): 71 – 75.
Amako, N.F. (1999). Studies of some phytochemical and cytotoxic principles of leaves and seeds extract of Crotalaria retusa L. Being an M.Sc Organic Chemistry Thesis. Dept. Of Chemistry, A.B.U, Zaria. Unpublished. Pp10; 39.
Be the first to comment